Bone formation in record time and without waste

More bone in less time

Nanosynt is a synthetic biphasic calcium phosphate-based bone replacement material (60% hydroxyapatite and 40% tricalcium ß-phosphate), non-toxic, radiopaque and highly biocompatible. It has excellent osteoconductive action, being resorbed and replaced by living bone tissue during bone remodeling.

  • Indications

    • Small or medium intraoral and maxillofacial bone defects with at least 3 remaining supporting walls.

    • Reconstruction / alveolar filling of 1 or several elements (eg after extraction).

    • Reconstruction (horizontal and vertical) in cases of bone defect in the alveolar ridge.

    • Sinus lift.

    • Periodontal regenerative treatment.

    • Filling of bone defects after apicectomy, removal of bone cysts and corrective osteotomy.

    • Perimplant regenerative treatment.

    Commercial Availability

    • 200 a 500µm – 4 portions of 0,27cc

    • 200 a 500µm – 2 portions of 0,27cc

    • 500 a 1000µm – 4 portions of 0,27cc

    • 500 a 1000µm – 2 portions of 0,27cc

    Advantages

    HIGH POROSITY (80 TO 90%)

    It favors vascularization, osteoblast migration and bone deposition, and avoids the encapsulation of bone tissue forming by fibrous connective tissue.

    SECURITY

    100% synthetic, contributing to your biological safety by eliminating any risk of contamination.

    EXCELLENT HYDRATION

    5 to 8 drops per serving (0.25g) – Hydrate dropwise.

    OSTEOCONDUCTIVE

    As it has excellent osteoconductive structure, it allows vascularization and cellular deposition.

    PRACTICALITY

    Available in fractionated form (4 or 2 0,27cc ampoules), allowing for simple and practical application, resulting in minimal material waste.

    EXCELLENT HANDLING

    Easily and safely mixes with sterile saline, blood or autogenous bone, filling the bone defect with ease.

    Scientifically proven effectiveness

    Nanosynt: histological and histomorphometric evaluation of a new bone substitute. The use of nanotechnology to achieve a better osteoconduction pattern.

    CONCLUSION

    “All biomaterials demonstrated similar behaviors throughout the study in histomorphometric, histological and biocompatibility characteristics. However, Nanosynt synthetic material had a higher level of bone formation and defect space maintenance when compared to Concurrent 1 and Concurrent 2 during the two in vivo periods of the present study.”

    Percentage of bone, remaining biomaterial and soft tissue in the evaluated periods.

    SOURCE: Freitas G., Tovar N., Ganato R., Marin C., Rabbit P.G. NanoSynt: Histological and histomorphometric evaluation of a new bone substitute. The use of nanotechnology to achieve a better osteoconduction pattern. ImplantNews. 2014; 11 (3): 296–301.

    SOURCE: Mayan MDC. Double blind randomized controlled trial for biological evaluation of two synthetic bone substitutes. Niterói – RJ; 2014

    Double-blind randomized controlled trial for biological evaluation of two synthetic bone substitutes

    CONCLUSION

    “After the conclusion of this clinical trial we can conclude that from the clinical point of view both experimental materials are easy to handle, excellent manipulation for alveolar filling and radiographically enough radiopaque for imaging follow-up.

    Both materials are biocompatible and osteoconductive. Both allowed implant placement after 3 and 6 months without complications or loss of the implants and preserved the alveolar architecture. The Biomaterial Group 1 (Nanosynt) after 6 months showed a larger amount of newly formed bone when compared to the other groups. Both materials have been shown to be safe and effective for use in humans. ”

    Histomorphometric evaluation of experimental groups for newly formed bone after 3 and 6 months of implantation (n = 5). * = p <0.05 and ***=p <0.001.

    Record bone formation

    Studies reveal rapid bone formation when using Nanosynt. Figure 1 shows the presence of Nanosynt 30 days after surgery (in a rat skull cap), which demonstrates volume maintenance. Figure 2 shows a large cellular activity around the biomaterial, which leads to the formation of new bone. And in figure 3, we highlight the large amount of newly formed bone after a short time (30 days).

    FIGURE 1

    Areas in green show the presence of Nanosynt biomaterial after 30 days.

    FIGURE 2

    Yellow areas show cellular activity around the biomaterial, leading to new bone formation.

    FIGURE 3

    Blue areas show the newly formed bone after a short time (30 days).

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