Nanosynt is a synthetic biphasic calcium phosphate-based bone replacement material (60%
hydroxyapatite and 40% tricalcium ß-phosphate), non-toxic, radiopaque and highly
biocompatible. It has excellent osteoconductive action, being resorbed and replaced by living
bone tissue during bone remodeling.
Nanosynt: histological and histomorphometric evaluation of a new bone substitute. The
use of nanotechnology to achieve a better osteoconduction pattern.
“All biomaterials demonstrated similar behaviors throughout the study in histomorphometric,
histological and biocompatibility characteristics. However, Nanosynt synthetic material had a
higher level of bone formation and defect space maintenance when compared to Concurrent 1 and
Concurrent 2 during the two in vivo periods of the present study.”
Percentage of bone, remaining biomaterial and soft tissue in the evaluated
SOURCE: Freitas G., Tovar N., Ganato R., Marin C., Rabbit P.G.
NanoSynt: Histological and histomorphometric evaluation of a new bone substitute. The use of
nanotechnology to achieve a better osteoconduction pattern. ImplantNews. 2014; 11 (3):
SOURCE: Mayan MDC. Double blind randomized controlled trial for
biological evaluation of two synthetic bone substitutes. Niterói – RJ; 2014
Double-blind randomized controlled trial for biological evaluation of two synthetic bone
“After the conclusion of this clinical trial we can conclude that from the clinical point of
view both experimental materials are easy to handle, excellent manipulation for alveolar
filling and radiographically enough radiopaque for imaging follow-up.
Both materials are biocompatible and osteoconductive. Both allowed implant placement after 3
and 6 months without complications or loss of the implants and preserved the alveolar
architecture. The Biomaterial Group 1 (Nanosynt) after 6 months showed a larger amount of
newly formed bone when compared to the other groups. Both materials have been shown to be safe
and effective for use in humans. ”
Histomorphometric evaluation of experimental groups for newly formed bone after 3 and
6 months of implantation (n = 5). * = p <0.05 and ***=p <0.001.
Studies reveal rapid bone formation when using Nanosynt. Figure 1 shows the presence of
Nanosynt 30 days after surgery (in a rat skull cap), which demonstrates volume maintenance.
Figure 2 shows a large cellular activity around the biomaterial, which leads to the formation
of new bone. And in figure 3, we highlight the large amount of newly formed bone after a short
time (30 days).
Areas in green show the presence of Nanosynt biomaterial after 30
Yellow areas show cellular activity around the biomaterial,
leading to new bone formation.
Blue areas show the newly formed bone after a short time (30